Baseline JAK-STAT signaling maintains immune cell homeostasis

被引：0

作者：

Bock, Christoph ^{[1
,2
]}

Decker, Thomas ^{[3
]}

Mueller, Mathias ^{[4
]}

机构：

[1] CeMM, Vienna, Austria

[2] Med Univ Vienna, Vienna, Austria

[3] Univ Vienna, Max Perutz Labs, Vienna, Austria

[4] Vetmeduni Vienna, Vienna, Austria

来源：

NATURE IMMUNOLOGY | 2024年 / 25卷 / 05期

关键词：

D O I：

10.1038/s41590-024-01805-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Homeostatic immune cells remain perpetually vigilant against pathogens. We found that baseline JAK-STAT signaling supports the characteristic transcriptional and epigenetic state of homeostatic T cells and macrophages in mice. JAK-STAT signaling under homeostatic conditions was driven by signals from healthy tissue and did not require external immune stimuli.

引用

页码：741 / 742

页数：42

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