Induction of the differentiation of human HL-60 promyelocytic leukemia cell line by succinoyl trehalose lipids

被引：0

作者：

Toshihiko Sudo

Xiaoxian Zhao

Yoko Wakamatsu

Miki Shibahara

Nobuhiko Nomura

Tadaatsu Nakahara

Akemi Suzuki

Yoshiro Kobayashi

Chunyuan Jin

Takehide Murata

Kazunari K. Yokoyama

机构：

[1] RIKEN (The Institute of Physical and Chemical Research),Tsukuba Life Science Center

[2] University of Tsukuba,Institute of Applied Biochemistry

[3] The Tokyo Metropolitan Institute of Medical Science,Department of Membrane Biochemistry

[4] Toho University,Department of Biomolecular Science, Faculty of Science

[5] RIKEN (The Institute of Physical and Chemical Research),Tsukuba Life Science Center

来源：

Cytotechnology | 2000年 / 33卷

关键词：

differentiation; glycolipid; HL-60 cells; succinoyl trehalose lipids;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Four analogs of succinoyl trehalose lipid-3 (STL-3)with saturated even-number or odd-number carbonchains, and unsaturated or halogenated fatty acidswere examined for their ability to inhibit the growthand induce the differentiation of HL-60 humanpromyelocytic leukemia cells. The optimalconcentration of STL-3 at which such activities wererecognized was closed to the critical micelleconcentration of STL-3. Analog of STL-3 witheven-number or odd-number carbon chain and unsaturatedfatty acids strongly inhibited growth and induced thedifferentiation of HL-60 cells, as evaluated in termsof nitroblue tetrazilium-reducing activity and theappearance of the CD36 antigen. An analog of STL-3with halogenated fatty acids significantly inhibitedproliferation but only induced the differentiation ofHL-60 cells. Our results indicate that the effects ofSTL-3 and its analogs on HL-60 cells depend on thestructure of the hydrophobic moiety of STL-3.

引用

页码：259 / 264

页数：5

共 42 条

[1]

Ishigami Y(1996)Relationship between structure and functions of biosurfactants J Jpn Oil Chem Soc 45 229-242

[2]

Isoda H(1997)Microbial extracellular glycolipid induction of differentiation and inhibition of the protein kinase C activity of human promyelocytic leukemia cell line HL-60 Biosci Biotech Biochem 61 609-614

[3]

Kitamoto D(1980)Relationship of structure to properties in surfactants J Phys Chem 84 547-551

[4]

Shinmoto H(1986)Ganglioside GM3: an acidic membrane component that increases during macrophage-like cell differentiation can induce monocytic differentiation of human myeloid and monocytoid leukemia cell lines HL-60 and U937 Proc Natl Acad Sci USA 83 782-786

[5]

Matsumura M(1988)Neolacto-series gangliosides induce granulocytic differentiation of human promyelocytic leukemia cell line HL-60 J Biol Chem 263 7443-7446

[6]

Nakahara T(1994)Regulation of expression of integrin and other adhesion molecules during differentiation of monocytes into macrophages Cell Immunol 156 191-211

[7]

Kwan CC(1985)An acidic glycosphingolipid, monosialo-ganglioside GM3, is a potent physiological inducer for monocytic differentiation of human promyelocytic leukemia cell line HL-60 cells Biochem Biophys Res Commun 132 223-231

[8]

Rosen MJ(1988)Effect of fibroblast-derived differentiation-inducing factor on the differentiation of human monocytoid and myeloid leukemia cell lines Biochem Biophys Res Commun 155 24-31

[9]

Nojiri H(1989)Extracellular accumulation of mono-and di-succinoyl trehalose lipid by a strain of Agric Biol Chem 53 757-763

[10]

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