Mammary stem cells, self-renewal pathways, and carcinogenesis

被引：0
作者：
Suling Liu
Gabriela Dontu
Max S Wicha
机构：
[1] University of Michigan,Comprehensive Cancer Center, Department of Internal Medicine
来源：
Breast Cancer Research | / 7卷
关键词：
Stem Cell; Mammary Gland; Mouse Mammary Tumor Virus; Notch Pathway; Hedgehog Signaling;
D O I：
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摘要：
The mammary gland epithelial components are thought to arise from stem cells that undergo both self-renewal and differentiation. Self-renewal has been shown to be regulated by the Hedgehog, Notch, and Wnt pathways and the transcription factor B lymphoma Mo-MLV insertion region 1 (Bmi-1). We review data about the existence of stem cells in the mammary gland and the pathways regulating the self-renewal of these cells. We present evidence that deregulation of the self-renewal in stem cells/progenitors might be a key event in mammary carcinogenesis. If 'tumor stem cells' are inherently resistant to current therapies, targeting stem cell self-renewal pathways might provide a novel approach for breast cancer treatment.
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