Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels

[1] DeFronzo RA(2009)Skeletal muscle insulin resistance is the primary defect in type 2 diabetes Diabetes Care 32 S157-S163

[2] Tripathy D(2014)Branched-chain amino acids in metabolic signalling and insulin resistance Nat Rev Endocrinol 10 723-736

[3] Lynch CJ(2016)A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance Nat Med 22 421-426

[4] Adams SH(2012)Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways Nat Genet 44 991-1005

[5] Jang C(2016)Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA Nat Commun 7 11122-4387

[6] Oh SF(2014)Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity Diabetes 63 4378-9192

[7] Wada S(2012)Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase J Biol Chem 287 9178-S11

[8] Scott RA(2012)Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care BMC Public Health 12 1078-3069

[9] Lagou V(2000)The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening Int J Obes Relat Metab Disord 24 S6-511

[10] Welch RP(2013)Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study Diabetes Care 36 3062-116

[1] DeFronzo RA(2009)Skeletal muscle insulin resistance is the primary defect in type 2 diabetes Diabetes Care 32 S157-S163

[2] Tripathy D(2014)Branched-chain amino acids in metabolic signalling and insulin resistance Nat Rev Endocrinol 10 723-736

[3] Lynch CJ(2016)A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance Nat Med 22 421-426

[4] Adams SH(2012)Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways Nat Genet 44 991-1005

[5] Jang C(2016)Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA Nat Commun 7 11122-4387

[6] Oh SF(2014)Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity Diabetes 63 4378-9192

[7] Wada S(2012)Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase J Biol Chem 287 9178-S11

[8] Scott RA(2012)Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care BMC Public Health 12 1078-3069

[9] Lagou V(2000)The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening Int J Obes Relat Metab Disord 24 S6-511

[10] Welch RP(2013)Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study Diabetes Care 36 3062-116