Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels

被引:0
作者
Yuvaraj Mahendran
Anna Jonsson
Christian T. Have
Kristine H. Allin
Daniel R. Witte
Marit E. Jørgensen
Niels Grarup
Oluf Pedersen
Tuomas O. Kilpeläinen
Torben Hansen
机构
[1] University of Copenhagen,Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences
[2] The Danish Diabetes Academy,Institute of Public Health
[3] University of Aarhus,undefined
[4] Steno Diabetes Center,undefined
来源
Diabetologia | 2017年 / 60卷
关键词
Branched-chain amino acids; Fasting insulin variants; Genetic risk score; Insulin resistance; Mendelian randomisation;
D O I
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中图分类号
学科分类号
摘要
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页码:873 / 878
页数:5
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[1]  
DeFronzo RA(2009)Skeletal muscle insulin resistance is the primary defect in type 2 diabetes Diabetes Care 32 S157-S163
[2]  
Tripathy D(2014)Branched-chain amino acids in metabolic signalling and insulin resistance Nat Rev Endocrinol 10 723-736
[3]  
Lynch CJ(2016)A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance Nat Med 22 421-426
[4]  
Adams SH(2012)Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways Nat Genet 44 991-1005
[5]  
Jang C(2016)Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA Nat Commun 7 11122-4387
[6]  
Oh SF(2014)Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity Diabetes 63 4378-9192
[7]  
Wada S(2012)Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase J Biol Chem 287 9178-S11
[8]  
Scott RA(2012)Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care BMC Public Health 12 1078-3069
[9]  
Lagou V(2000)The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening Int J Obes Relat Metab Disord 24 S6-511
[10]  
Welch RP(2013)Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study Diabetes Care 36 3062-116