Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis

被引：0
作者：
Yunyuan Zhang
Chunming Ding
Jing Wang
Guirong Sun
Yongxian Cao
Longqiang Xu
Lan Zhou
Xian Chen
机构：
[1] The Affiliated Hospital of Qingdao University,Department of Clinical Laboratory
[2] Qingdao Municipal Hospital,Department of Orthopaedics
[3] Chongqing Medical University,College of Laboratory Medicine, Key Laboratory of Laboratory Medical Diagnostics designated by Chinese Ministry of Education
[4] The University of Chicago Medical Center,Molecular Oncology Laboratory, Department of Orthopaedic Surgery
来源：
Journal of Orthopaedic Surgery and Research | / 10卷
关键词：
CD44V6; Osteosarcoma; Prognosis; Meta-analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Numerous individual studies evaluating the relationship between CD44V6 over-expression and prognostic impact in patients with osteosarcoma (OS) have yielded in conclusive results. This meta-analysis aimed to determine the value of cell adhesion molecule CD44V6 in prognosis of OS by conducting a systematic review and meta-analysis. A comprehensive search was conducted using PubMed (medline), Embase, ISI Web of Knowledge, Springer, the Cochrane Library, Scopus, BioMed Central, ScienceDirect, Wanfang, Weipu, and China National Knowledge Internet (CNKI) databases from inception through May 26, 2015. All available articles written in English or Chinese that investigated the expression of CD44V6 and the prognosis of OS were included. The quantity of the studies was evaluated according to the critical review checklist of the Dutch Cochrane Centre proposed by MOOSE. Finally, a total of eight studies with 486 OS patients were involved and the results indicated that the positive expression of CD44V6 predicts neoplasm metastasis (RR = 1.76, 95 % CI 1.38–2.25, p < 0.00001), and poor survival in OS with the pooled HR of 1.53 (95 % CI 1.25–1.88, p < 0.0001). No significant heterogeneity was observed among all studies. In conclusion, the present meta-analysis and systematic review strongly suggest that CD44V6 over-expression is associated with overall survival rate and metastasis in OS, and may be used as a prognostic biomarker to guide the clinical therapy for OS.
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