A novel pyrazoline-based fluorescence probe armed by pyrene and naphthol system for the selective detection of Cu2+ and its biological application

被引：0
作者：
Yun-Shang Yang
Jing-Qi Cao
Chun-Mei Ma
Ying-Peng Zhang
Hui-Chen Guo
Ji-Jun Xue
机构：
[1] Lanzhou University of Technology,School of Petrochemical Engineering
[2] Lanzhou Veterinary Research Institute,State Key Laboratory of Veterinary Etiological Biology and National Foot and Mouth Disease Reference Laboratory
[3] Chinese Academy of Agricultural Sciences,State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering
[4] Lanzhou University,undefined
来源：
Journal of the Iranian Chemical Society | 2022年 / 19卷
关键词：
Pyrazoline; Fluorescent chemosensor; Copper ions; DFT calculation; Cell imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A photo-induced electron transfer cationic fluorescence probe L1 based on pyrene-naphthol system was designed to detect the change of Cu2+ with fluorescence. The probe L1 was found to selectively recognize Cu2+ in aqueous ethanol solution [10.0 mmol/L HEPES, pH 7.4, EtOH–H2O = 1:1 (v/v)] without interference from other coexisting metal ions. The response of the sensor to Cu2+ is transient and reversible, and anions generally have no impact on the selectivity of Cu2+. Probe L1 forms complex with Cu2+ in 1:1 ratio as supported by Job’s plot analysis. The binding constants of Cu2+ was calculated to be 6.322 × 104 L/mol using a nonlinear curve-fitting method. The detection limit of Cu2+ was determined to be 1.620 × 10–7 mol/L. The energy gap between HOMO and LUMO in L1 and L1–Cu2+ was calculated by density functional theory as 3.76 eV and 2.71 eV, respectively. In addition, the probe L1 has extremely low cytotoxicity and can be used for living cell imaging studies.
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页码：3451 / 3461
页数：10
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