New developments in ochronosis: review of the literature

被引：0
作者：
Julie M. Keller
William Macaulay
Ohannes A. Nercessian
Israeli A. Jaffe
机构：
[1] Columbia University Medical Center,Department of Orthopedic Surgery
[2] Columbia University Medical Center,Division of Rheumatology
[3] Center for Hip and Knee Replacement,undefined
来源：
Rheumatology International | 2005年 / 25卷
关键词：
Alkaptonuria; Arthrosis; Connective tissue manifestations; Diagnosis; Ochronosis; Review;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Ochronosis commonly affects all connective tissue. Recognition of changes secondary to the deposition of ochronotic pigments has increased with advances in diagnostic technology, allowing both improved imaging and early biochemical and genetics-based diagnosis of alkaptonuria, the cause of ochronosis. Successful symptomatic treatment of ochronotic arthropathy with joint replacement has been documented, and a new pharmacotherapeutic agent, nitisinone, is currently under investigation for both prevention and treatment of ochronosis. This review of the literature highlights recently recognized complications, new diagnostic techniques, and treatment options.
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页码：81 / 85
页数：4
相关论文
共 22 条
  • [1] Selvi A(2000)Alkaptonuria and lumbar disc herniation J Rheumatol 27 2272-9
  • [2] Sahin G(2001)undefined Rheumatol Int 21 78-undefined
  • [3] Kumar S(2003)undefined J Bone Joint Surg Br 85 883-undefined
  • [4] Farzannia undefined(2003)undefined J Neurosurg (Spine 98 87-undefined
  • [5] Shokouhi undefined(1999)undefined Int Orthop 23 122-undefined
  • [6] Hadidchi undefined(1970)undefined J Bone Joint Surg Br 52 653-undefined
  • [7] Hamdi undefined(2001)undefined J Inher Metab Dis 24 824-undefined
  • [8] Laskar undefined(2000)undefined J Arthroplasty 15 539-undefined
  • [9] Ellaway undefined(2002)undefined N Engl J Med 347 2111-undefined
  • [10] Aydogdu undefined(2002)undefined Clin Rheumatol 21 170-undefined
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