Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis

被引：0
|
作者：
Isao Sakaida
Koichi Uchida
Koji Hironaka
Kiwamu Okita
机构：
[1] First Department of Internal Medicine,
[2] School of Medicine,undefined
[3] Yamaguchi University,undefined
[4] 1144 Kogushi,undefined
[5] Ube 755-8505,undefined
[6] Japan,undefined
来源：
Journal of Gastroenterology | 1999年 / 34卷
关键词：
Key words: prolyl 4-hydroxylase inhibitor; procollagen; tissue inhibitor of metalloproteinase-1 (TIMP-1);
D O I：
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学科分类号：
摘要：
The effects of a prolyl 4-hydroxylase inhibitor (HOE 077) on tissue inhibitor of metalloproteinase-1 (TIMP-1) and procollagen type I were examined in rat liver fibrosis. HOE 077 (200 ppm) prevented fibrosis by inhibiting the expression of liver type I procollagen and TIMP-1 mRNAs, with liver hydroxyroline content correlated with the reduction in activated stellate cells. HOE 077 prevents fibrosis by inhibiting proline hydroxylation and stellate cell activation, resulting in reduced expression of procollagen and TIMP-1 mRNAs.
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页码：376 / 377
页数：1
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