Variants in circadian genes and prostate cancer risk: a population-based study in China

被引：0
作者：
L W Chu
Y Zhu
K Yu
T Zheng
H Yu
Y Zhang
I Sesterhenn
A P Chokkalingam
K N Danforth
M-C Shen
F Z Stanczyk
Y-T Gao
A W Hsing
机构：
[1] Cancer Prevention Fellowship Program,Division of Cancer Prevention
[2] Office of Preventive Oncology,Department of Epidemiology and Public Health
[3] National Cancer Institute,Division of Cancer Epidemiology and Genetics
[4] National Institutes of Health,Department of Epidemiology
[5] Yale University School of Medicine,Department of Obstetrics and Gynecology
[6] National Cancer Institute,Department of Epidemiology
[7] National Institutes of Health,undefined
[8] Armed Forces Institute of Pathology,undefined
[9] School of Public Health,undefined
[10] University of California at Berkeley,undefined
[11] Shanghai Tumor Hospital,undefined
[12] Fudan University,undefined
[13] Keck School of Medicine,undefined
[14] University of Southern California,undefined
[15] Shanghai Cancer Institute,undefined
来源：
Prostate Cancer and Prostatic Diseases | 2008年 / 11卷
关键词：
circadian genes; genetic polymorphisms; China;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Circadian genes influence a variety of biological processes that are important in prostate tumorigenesis including metabolism. To determine if variants in circadian genes alter prostate cancer risk, we genotyped five variants in five circadian genes in a population-based case–control study conducted in China (187 cases and 242 controls). These variants included CRY2 rs1401417:G>C, CSNK1E rs1005473:A>C, NPAS2 rs2305160:G>A, PER1 rs2585405:G>C and PER3 54-bp repeat length variant. Men with the cryptochrome 2 (CRY2)-variant C allele had a significant 1.7-fold increased prostate cancer risk (95% confidence interval (CI), 1.1–2.7) relative to those with the GG genotype. This risk increased to 4.1-fold (95% CI, 2.2–8.0) in men who also had greater insulin resistance (IR) as compared to men with the GG genotype and less IR. In contrast, among men with less IR, the NPAS2-variant A allele was associated with decreased prostate cancer risk (odds ratio=0.5, 95% CI, 0.3–1.0) as compared to the GG genotype. Our findings, although in need of confirmation, suggest that variations in circadian genes may alter prostate cancer risk and some biological processes may modify this effect.
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页码：342 / 348
页数：6
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