Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles

被引:0
作者
Rosie M. Walker
Kadi Vaher
Mairead L. Bermingham
Stewart W. Morris
Andrew D. Bretherick
Yanni Zeng
Konrad Rawlik
Carmen Amador
Archie Campbell
Chris S. Haley
Caroline Hayward
David J. Porteous
Andrew M. McIntosh
Riccardo E. Marioni
Kathryn L. Evans
机构
[1] University of Edinburgh,Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine
[2] Present Address: Centre for Clinical Brain Sciences,MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine
[3] Chancellor’s Building,Present address: Faculty of Forensic Medicine, Zhongshan School of Medicine
[4] Present Address: MRC Centre for Reproductive Health,Division of Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies
[5] The Queen’s Medical Research Institute,Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine
[6] Edinburgh BioQuarter,Division of Psychiatry
[7] University of Edinburgh,undefined
[8] Sun Yat-Sen University,undefined
[9] University of Edinburgh,undefined
[10] Easter Bush,undefined
[11] University of Edinburgh,undefined
[12] University of Edinburgh,undefined
[13] Royal Edinburgh Hospital,undefined
来源
Genome Medicine | / 13卷
关键词
Alzheimer’s disease; APOE; Apolipoprotein E; DNA methylation; Cholesterol; Lipids;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 354 条
  • [1] Lambert JC(2013)Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease Nat Genet 45 1452-1458
  • [2] Ibrahim-Verbaas CA(2019)Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing Nat Genet 51 414-430
  • [3] Harold D(2019)Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk Nat Genet 51 404-413
  • [4] Naj AC(1993)Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families Science. 261 921-923
  • [5] Sims R(1997)Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium JAMA. 278 1349-1356
  • [6] Bellenguez C(2019)ApoE4: an emerging therapeutic target for Alzheimer’s disease BMC Med 17 64-346
  • [7] Kunkle BW(2019)Invited review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer’s disease Neuropathol Appl Neurobiol 45 327-1163
  • [8] Grenier-Boley B(2017)APOE-related risk of mild cognitive impairment and dementia for prevention trials: an analysis of four cohorts PLoS Med 14 e1002254-1170
  • [9] Sims R(2018)Haplotype analysis of APOE intragenic SNPs BMC Neurosci 19 16-86
  • [10] Bis JC(2014)Alzheimer’s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci Nat Neurosci 17 1156-5047