Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer

被引:0
作者
Yoshitaro Shindo
Shoichi Hazama
Yoshinari Maeda
Hiroto Matsui
Michihisa Iida
Nobuaki Suzuki
Kiyoshi Yoshimura
Tomio Ueno
Shigefumi Yoshino
Kohei Sakai
Yutaka Suehiro
Takahiro Yamasaki
Yuji Hinoda
Masaaki Oka
机构
[1] Yamaguchi University Graduate School of Medicine,Department of Digestive Surgery and Surgical Oncology (Department of Surgery II)
[2] Yamaguchi University School of Medicine,Department of Oncology and Laboratory Medicine
来源
Journal of Translational Medicine | / 12卷
关键词
Pancreatic cancer; MUC1; Dendritic cell; Cytotoxic lymphocyte; Gemcitabine; Immunotherapy;
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[1]  
Jemal A(2010)Cancer statistics, 2010 CA Cancer J Clin 60 277-300
[2]  
Siegel R(1997)Adjuvant therapy of pancreatic cancer using monoclonal antibodies and immune response modifiers Int J Pancreatol 21 43-52
[3]  
Xu J(1991)Phase II studies of recombinant human tumor necrosis factor alpha in patients with malignant disease: a summary of the Southwest Oncology Group experience J Immunother (1991) 10 426-431
[4]  
Ward E(2002)Detection of peptide-specific cytotoxic T-lymphocyte precursors used for specific immunotherapy of pancreatic cancer Int J Cancer 98 45-50
[5]  
Friess H(1994)Phase II trials of high-dose interleukin-2 and lymphokine-activated killer cells in advanced breast carcinoma and carcinoma of the lung, ovary, and pancreas and other tumors J Immunother Emphasis Tumor Immunol 16 216-223
[6]  
Gassmann M(2010)Tumor antigen presentation by dendritic cells Crit Rev Immunol 30 345-386
[7]  
Buchler MW(2004)Analysis of T-cell responses in metastatic melanoma patients vaccinated with dendritic cells pulsed with tumor lysates Cancer Immunol Immunother 53 715-722
[8]  
Hersh EM(2001)Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer Hepatogastroenterology 48 347-351
[9]  
Metch BS(2008)A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors Cancer Ther 6 955-964
[10]  
Muggia FM(1990)Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin J Biol Chem 265 15286-15293