Anticancer drug discovery and pharmaceutical chemistry: A history

被引：6

作者：

Braña M.F. ^{[1
,3
]}

Sánchez-Migallón A. ^{[2
]}

机构：

[1] Instituto Canario de Investigación del Cáncer (ICIC), 28110 Algete, Madrid

[2] Universidad de Castilla-La Mancha, Castilla-La Mancha

[3] 28110 Algete, Madrid

来源：

Clinical and Translational Oncology | 2006年 / 8卷 / 10期

关键词：

Drug design; Drug discovery; Organic chemistry of anticancer drugs;

D O I：

10.1007/s12094-006-0118-5

中图分类号：

学科分类号：

摘要：

There are several procedures for the chemical discovery and design of new drugs from the point of view of the pharmaceutical or medicinal chemistry. They range from classical methods to the very new ones, such as molecular modeling or high throughput screening. In this review, we will consider some historical approaches based on the screening of natural products, the chances for luck, the systematic screening of new chemical entities and serendipity. Another group comprises rational design, as in the case of metabolic pathways, conformation versus configuration and, finally, a brief description on available new targets to be carried out. In each approach, the structure of some examples of clinical interest will be shown. © FESEO 2006.

引用

页码：717 / 728

页数：11

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