Zinc fingers and homeoboxes family in human diseases

被引：0
作者：
Y Liu
D Ma
C Ji
机构：
[1] Qilu Hospital,Department of Hematology
[2] Shandong University,undefined
来源：
Cancer Gene Therapy | 2015年 / 22卷
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摘要：
The zinc-fingers and homeoboxes (ZHX) family is a group of nuclear homodimeric transcriptional repressors that interact with a subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. The members of ZHX family form homodimers or heterodimers with other members or a subunit of NF-YA to repress transcription. ZHX family members function in hematopoietic cell development and differentiation, and neural progenitor maintenance. Dysfunction of ZHX family members correlates with the development and progression of various diseases, including hepatocellular carcinoma (HCC), hematological diseases, neurological diseases and glomerular diseases. Furthermore, low expression of ZHX is associated with poor prognosis in malignancies. This review provides an update on the role of ZHX family in development and its function in cancer, with special emphasis on HCC and hematological malignant diseases.
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页码：223 / 226
页数：3
相关论文
共 257 条
[1]  
Barthelemy I(1996)Zhx-1: a novel mouse homeodomain protein containing two zinc-fingers and five homeodomains Biochem Biophys Res Commun 224 870-876
[2]  
Carramolino L(2003)The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3 Gene 323 133-140
[3]  
Gutiérrez J(2003)Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor Biochem J 373 747-757
[4]  
Barbero JL(2003)Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3 Biochem J 373 167-178
[5]  
Márquez G(1999)Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y Biochem Biophys Res Commun 261 614-621
[6]  
Zaballos A(2002)Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer Gene 290 107-114
[7]  
Kawata H(1998)Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins DNA Res 5 355-364
[8]  
Yamada K(2011)Lack of association of G779A ZHX-2 gene variant with HbF levels in beta-thalassemia major Eur J Haematol 86 502-506
[9]  
Shou Z(2012)Genome-wide association study of antibody response to smallpox vaccine Vaccine 30 4182-4189
[10]  
Mizutani T(1997)Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins DNA Res 4 307-313
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