Network mirroring for drug repositioning

[1] Hughes J(2011)Principles of early drug discovery Br J Pharmacol 162 1239-1249

[2] Rees S(2004)Drug repositioning: identifying and developing new uses for existing drugs Nat Rev Drug Discov 3 673-683

[3] Kalindjian S(2012)Diagnosing the decline in pharmaceutical R&D efficiency Nat Rev Drug Discov 11 191-200

[4] Philpott K(2012)Drug discovery in pharmaceutical industry: productivity challenges and trends Drug Discov Today 17 1088-1102

[5] Ashburn TT(1998)Oral sildenafil in the treatment of erectile dysfunction N Engl J Med 338 1397-1404

[6] Thor KB(1999)Antitumor activity of thalidomide in refractory multiple myeloma N Engl J Med 341 1565-1571

[7] Scannell JW(2006)The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease Science 313 1929-1935

[8] Blanckley A(2009)Predicting new molecular targets for known drugs Nature 462 175-181

[9] Boldon H(2010)Drug off-target effects predicted using structural analysis in the context of a metabolic network model PLoS Comput Biol 6 e1000938-266

[10] Warrington B(2009)Systematic evaluation of drug-disease relationships to identify leads for novel drug uses Clin Pharmacol Ther 86 507-115

[1] Hughes J(2011)Principles of early drug discovery Br J Pharmacol 162 1239-1249

[2] Rees S(2004)Drug repositioning: identifying and developing new uses for existing drugs Nat Rev Drug Discov 3 673-683

[3] Kalindjian S(2012)Diagnosing the decline in pharmaceutical R&D efficiency Nat Rev Drug Discov 11 191-200

[4] Philpott K(2012)Drug discovery in pharmaceutical industry: productivity challenges and trends Drug Discov Today 17 1088-1102

[5] Ashburn TT(1998)Oral sildenafil in the treatment of erectile dysfunction N Engl J Med 338 1397-1404

[6] Thor KB(1999)Antitumor activity of thalidomide in refractory multiple myeloma N Engl J Med 341 1565-1571

[7] Scannell JW(2006)The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease Science 313 1929-1935

[8] Blanckley A(2009)Predicting new molecular targets for known drugs Nature 462 175-181

[9] Boldon H(2010)Drug off-target effects predicted using structural analysis in the context of a metabolic network model PLoS Comput Biol 6 e1000938-266

[10] Warrington B(2009)Systematic evaluation of drug-disease relationships to identify leads for novel drug uses Clin Pharmacol Ther 86 507-115