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Effects of Prulifloxacin on Cardiac Repolarization in Healthy SubjectsA Randomized, Crossover, Double-Blind versus Placebo, Moxifloxacin-Controlled Study
被引：0
|作者：
Maria Teresa Rosignoli
Giorgio Di Loreto
Paolo Dionisio
机构：
[1] ACRAF SpA,Headquarters Medical Department, Angelini Pharmaceuticals
[2] ACRAF SpA,Angelini Pharmaceuticals
来源：
Clinical Drug Investigation
|
2010年
/
30卷
关键词：
Moxifloxacin;
Ranolazine;
Sparfloxacin;
Grepafloxacin;
Gemifloxacin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background and Objective: Prulifloxacin, a broad-spectrum fluoroquinolone, is quantitatively transformed after oral administration into ulifloxacin, the active metabolite. On the basis of preclinical data suggesting that prulifloxacin is not likely to prolong the QT interval, a trial to assess the potential effects of prulifloxacin on QT and corrected QT (QTc) interval in humans was performed.
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页码：5 / 14
页数：9
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