The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian cancer cells in vitro

被引：0
作者：
Magdalena Klink
Marek Nowak
Michał Kielbik
Katarzyna Bednarska
Edyta Blus
Marian Szpakowski
Krzysztof Szyllo
Zofia Sulowska
机构：
[1] Polish Academy of Sciences,Institute of Medical Biology
[2] Polish Mother’s Memorial Hospital—Research Institute,Department of Gynecology
[3] Polish Mother’s Memorial Hospital—Research Institute,Department of Operative Gynecology
来源：
Cell Stress and Chaperones | 2012年 / 17卷
关键词：
Heat shock protein; Toll-like receptors; Neutrophils; Ovarian cancer cells;
D O I：
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学科分类号：
摘要：
Inducible heat shock protein (HspA1A) promotes tumor cell growth and survival. It also interacts with effector cells of the innate immune system and affects their activity. Recently, we showed that the direct contact of ovarian cancer cells, isolated from tumor specimens, with neutrophils intensified their biological functions. Our current experiments demonstrate that the activation of neutrophils, followed by an increased production of reactive oxygen species, by cancer cells involves the interaction of HspA1A from cancer cells with Toll-like receptors 2 and 4 expressed on the neutrophils’ surface. Our data may have a practical implication for targeted anticancer therapies based, among other factors, on the inhibition of HspA1A expression in the cancer cells.
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页码：661 / 674
页数：13
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