Signaling pathway switch in breast cancer

被引：0
作者：
Arnaud Guille
Max Chaffanet
Daniel Birnbaum
机构：
[1] Aix-Marseille Université,Centre de Recherche en Cancérologie de Marseille, Oncologie Moléculaire, “Equipe labellisée Ligue Contre le Cancer”, UMR1068 Inserm, CNRS UMR7258, Institut Paoli
来源：
Cancer Cell International | / 13卷
关键词：
Next generation sequencing; Breast cancer; Signaling pathways; Cell cycle; Kinases;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells
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