Signaling pathway switch in breast cancer

被引：0

作者：

Arnaud Guille

Max Chaffanet

Daniel Birnbaum

机构：

[1] Aix-Marseille Université,Centre de Recherche en Cancérologie de Marseille, Oncologie Moléculaire, “Equipe labellisée Ligue Contre le Cancer”, UMR1068 Inserm, CNRS UMR7258, Institut Paoli

来源：

Cancer Cell International | / 13卷

关键词：

Next generation sequencing; Breast cancer; Signaling pathways; Cell cycle; Kinases;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells

引用

共 50 条

[31] Deciphering Potential Role of Hippo Signaling Pathway in Breast Cancer: A Comprehensive Review [J].

Bhavnagari, Hunayna ;

Raval, Apexa ;

Shah, Franky .

CURRENT PHARMACEUTICAL DESIGN, 2023, 29 (44) :3505-3518

[32] Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variables [J].

Woo Chul Noh ;

Yang Hee Kim ;

Min Suk Kim ;

Jae Soo Koh ;

Hyun-Ah Kim ;

Nan Mo Moon ;

Nam-Sun Paik .

Breast Cancer Research and Treatment, 2008, 110 :477-483

[33] Role of regulatory miRNAs of the Wnt/ β-catenin signaling pathway in tumorigenesis of breast cancer [J].

Rahmani, Farzad ;

Tabrizi, Ayda Tadayyon ;

Hashemian, Pedram ;

Alijannejad, Sajede ;

Rahdar, Hossein Ali ;

Ferns, Gordon A. ;

Hassanian, Seyed Mahdi ;

Shahidsales, Soodabeh ;

Avan, Amir .

GENE, 2020, 754

[34] In Silico Identification of Potential Inhibitors of the Wnt Signaling Pathway in Human Breast Cancer [J].

Pinto, Icaro Alves ;

Freitas Da Silveira, Nelson Jose .

JOURNAL OF COMPUTATIONAL BIOLOGY, 2020, 27 (07) :999-1010

[35] SIRT1/FOXO Signaling Pathway in Breast Cancer Progression and Metastasis [J].

Dilmac, Sayra ;

Kuscu, Nilay ;

Caner, Ayse ;

Yildirim, Sendegul ;

Yoldas, Burcak ;

Farooqi, Ammad Ahmad ;

Tanriover, Gamze .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (18)

[36] Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variables [J].

Noh, Woo Chul ;

Kim, Yang Hee ;

Kim, Min Suk ;

Koh, Jae Soo ;

Kim, Hyun-Ah ;

Moon, Nan Mo ;

Paik, Nam-Sun .

BREAST CANCER RESEARCH AND TREATMENT, 2008, 110 (03) :477-483

[37] Unveiling the role of TGF-β signaling pathway in breast cancer prognosis and immunotherapy [J].

Zheng, Yifan ;

Li, Li ;

Cai, Wenqian ;

Li, Lin ;

Zhang, Rongxin ;

Huang, Wenbin ;

Cao, Yulun .

FRONTIERS IN ONCOLOGY, 2024, 14

[38] Hippo signaling pathway: A comprehensive gene expression profile analysis in breast cancer [J].

Yousefi, Hassan ;

Delavar, Mahsa Rostamian ;

Piroozian, Fatemeh ;

Baghi, Masoud ;

Nguyen, Khoa ;

Cheng, Thomas ;

Vittori, Cecilia ;

Worthylake, David ;

Alahari, Suresh K. .

BIOMEDICINE & PHARMACOTHERAPY, 2022, 151

[39] Extensive analysis of signaling pathway molecules in breast cancer: association with clinicopathological characteristics [J].

Horii, Rie ;

Matsuura, Masaaki ;

Dan, Shingo ;

Ushijima, Masaru ;

Uehiro, Natsue ;

Ogiya, Akiko ;

Honma, Naoko ;

Ito, Yoshinori ;

Iwase, Takuji ;

Yamori, Takao ;

Akiyama, Futoshi .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2015, 20 (03) :490-498

[40] Nanomaterials for delivery of drugs and genes to disrupt notch signaling pathway in breast cancer [J].

Gummadi, Ramakrishna ;

Nori, Lakshmi Prasanthi ;

Pindiprolu, Sai Kiran S. S. ;

Dasari, Nagasen ;

Ahmad, Zubair ;

Muhasina, K. M. .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2025,

← 1 2 3 4 5 →