Signaling pathway switch in breast cancer

被引：0

作者：

Arnaud Guille

Max Chaffanet

Daniel Birnbaum

机构：

[1] Aix-Marseille Université,Centre de Recherche en Cancérologie de Marseille, Oncologie Moléculaire, “Equipe labellisée Ligue Contre le Cancer”, UMR1068 Inserm, CNRS UMR7258, Institut Paoli

来源：

Cancer Cell International | / 13卷

关键词：

Next generation sequencing; Breast cancer; Signaling pathways; Cell cycle; Kinases;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells

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