Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma

被引：30
作者：
Feller L. [1 ]
Lemmer J. [1 ]
机构：
[1] Department of Periodontology and Oral Medicine, School of Dentistry, University of Limpopo Medunsa Campus, Pretoria
来源：
Infectious Agents and Cancer | / 3卷 / 1期
关键词：
Human Immunodeficiency Virus; Human Immunodeficiency Virus Infection; Immune Reconstitution Inflammatory Syndrome; Human Immunodeficiency Virus Load; Nitrative Metabolite;
D O I：
10.1186/1750-9378-3-1
中图分类号：
学科分类号：
摘要：
A decrease in the incidence of human immune deficiency virus-associated Kaposi sarcoma (HIV-KS) and regression of some established HIV-KS lesions is evident after the introduction of highly active anti-retroviral treatment (HAART), and is attributed to generalized immune restoration, to the reconstitution of human herpesvirus (HHV)-8 specific cellular immune responses, and to the decrease in HIV Tat protein and HHV-8 loads following HAART. However, a small subset of HIV-seropositive subjects with a low CD4+ T cell count at the time of introduction of HAART, may develop HIV-KS as immune reconstitution inflammatory syndrome (IRIS) within 8 weeks thereafter. © 2008 Feller and Lemmer; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 542 条
[1]  
Leao JC(2002)Human herpesvirus 8 (HHV-8) and the etiopathogenesis of Kaposi's sarcoma Rev Hosp Clin Fac Med Sao Paulo 57 175-186
[2]  
Caterino-de-Araujo A(1993)Kaposi's sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy J Am Acad Dermatol 28 371-395
[3]  
Porter SR(2005)The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma J Immunol 174 3686-3694
[4]  
Scully C(2004)Kaposi sarcoma and calcium channel blocker-induced gingival enlargement occurring simultaneously: Review of the literature and report of a case Oral Biosci Med 4 291-297
[5]  
Tappero JW(2005)Profile of patients with Kaposi's Sarcoma in the era of highly active antiretroviral therapy J Clin Oncol 23 1253-1260
[6]  
Conant MA(2002)Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 1: Epidemiology, environmental predispositions, clinical manifestations and therapy Lancet Infect Dis 2 281-292
[7]  
Wolfe SF(1997)Kaposi's sarcoma associated herpesvirus-like DNA sequences (KSHV/HHV-8) in oral AIDS-Kaposi's sarcoma: a PCR and clinicopathologic study Oral Surg Oral Med Oral Pathol Oral Radiol and Endod 83 259-264
[8]  
Berger TG(2003)Clinical presentations and standard therapy of AIDS-associated Kaposi's sarcoma Hematol Oncol Clin North Am 17 747-762
[9]  
Jensen KK(2003)HIV protease inhibitors: antiretroviral agents with anti-inflammatory, anti-angiogenic and anti-tumour activity J Antimicrob Chemother 51 207-211
[10]  
Manfra DJ(2002)Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 2: Pathogenesis, Castleman's disease and pleural effusion lymphoma Lancet Infect Dis 2 344-352
12345678910