Therapeutic efficacy of theophylline in chronic lymphocytic leukemia

被引：0
作者：
Della Makower
Ummekalsoom Malik
Yelena Novik
Peter H Wiernik
机构：
[1] Montefiore Medical Center/Albert Einstein Cancer Center,Department of Oncology
[2] Our Lady of Mercy Comprehensive Cancer Center,undefined
来源：
Medical Oncology | 1999年 / 16卷
关键词：
chronic lymphocytic leukemia; theophylline; apoptosis; methylxanthine; cyclic adenosine monophosphate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Theophylline, a methylxanthine commonly used as a treatment for asthma, has been shown to induce apoptosis in chronic lymphocytic leukemia (CLL) cells bothin vitro andin vivo. We have treated three advanced CLL patients with theophylline, and seen responses in two. The clinical courses of the responders are presented, and the literature concerning theophylline as therapy for CLL is reviewed.
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页码：69 / 71
页数：2
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