Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

被引:0
作者
Amir Faisal
Grace W Y Mak
Mark D Gurden
Cristina P R Xavier
Simon J Anderhub
Paolo Innocenti
Isaac M Westwood
Sébastien Naud
Angela Hayes
Gary Box
Melanie R Valenti
Alexis K De Haven Brandon
Lisa O'Fee
Jessica Schmitt
Hannah L Woodward
Rosemary Burke
Rob L M vanMontfort
Julian Blagg
Florence I Raynaud
Suzanne A Eccles
Swen Hoelder
Spiros Linardopoulos
机构
[1] Cancer Research UK Cancer Therapeutics Unit,Division of Cancer Therapeutics
[2] The Institute of Cancer Research,Division of Breast Cancer Research
[3] Breast Cancer Now,undefined
[4] The Institute of Cancer Research,undefined
[5] Present address: Lahore University of Management Sciences,undefined
[6] D.H.A. Lahore Cantt. 54792,undefined
[7] Lahore,undefined
[8] Pakistan.,undefined
[9] Present address: i3S—Instituto de Investigação e Inovação em Saúde da Universidade do Porto,undefined
[10] Rua Alfredo Allen 208,undefined
[11] Porto 4200-135,undefined
[12] Portugal.,undefined
[13] Present address: Phenex Pharmaceuticals,undefined
[14] 67059 Ludwigshafen am Rhein,undefined
[15] Germany.,undefined
来源
British Journal of Cancer | 2017年 / 116卷
关键词
MPS1; inhibition; spindle assembly checkpoint; pharmacodynamics;
D O I
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中图分类号
学科分类号
摘要
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页码:1166 / 1176
页数:10
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