Morphological response of the pineal gland of old animals to melatonin course injection

被引：0
作者：
Gubina-Vakulik G.I. [1 ]
Bondarenko L.A. [2 ]
Gevorkyan A.R. [2 ]
机构：
[1] Kharkiv National Medical University, Kharkiv, 61002
[2] Danilevsky Institute of Endocrine Pathology Problems, Ukrainian Academy of Medical Sciences, Kharkiv, 61002
来源：
Advances in Gerontology | 2011年 / 1卷 / 2期
关键词：
Melatonin; Pineal gland; Pinealocyte structure;
D O I：
10.1134/S207905701102007X
中图分类号：
学科分类号：
摘要：
The effect of 10-day-long evening melatonin injections in the physiological dose range on the morphological state of the pineal gland was studied in old (18 to 20 months old) rat males of the Wistar population. It was shown with the use of nucleic acids histochemical staining that melatonin course injection into old rats caused dose-dependant morphofunctional activation of pinealocytes that was accompanied by the increase in nuclei area, optical density of nuclei and cytoplasm. This fact was indicative of stimulation of epiphyseal hormone production of both indole and polypeptidic nature. The use of melatonin in a dose of 0.05 mg/kg of body mass was accompanied by polyploidization of pinealocytes nuclei, and a dose of 0.50 mg/kg of body mass induced forced apoptosis. © Pleiades Publishing, Ltd., 2011.
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页码：166 / 170
页数：4
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共 28 条
  • [1] Avtandilov G.G., Saniev K.B., Ploidometry in Improving the Quality of Pathohistologic Diagnosis, Arkh. Patol., 64, 3, pp. 31-33, (2002)
  • [2] Anisimov V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Aging), (2003)
  • [3] Anisimov V.N., The Effect of Melatonin on Aging Process, Melatonin v norme i patologii (Melatonin in Normal State and Pathologic Conditions), pp. 223-237, (2004)
  • [4] Anisimov V.N., Age-Related Changes of Epiphyseal Function, Melatonin v norme i patologii (Melatonin in Normal State and Pathologic Conditions), pp. 20-33, (2004)
  • [5] Arushanyan E.B., Unikalnyi melatonin (biologicheskie svoistva i farmakologiya) (Unique Melatonin (Biological Properties and Pharmacology), (2006)
  • [6] Belushkina N.N., Severin S.E., Molecular Mechanisms of Apoptosis Pathology, Arkh. Patol., 63, 1, pp. 51-60, (2001)
  • [7] Zhizhina G.P., The Role of Apoptosis in Normal Ontogenesis, Pathogenesis and Aging, Klin. Geront., 8, 4, pp. 3-10, (2002)
  • [8] Bondarenko L.A., Gorbach T.V., Gevorkyan A.R., Determination of Exogenic Melatonin Dose Regenerating the Concentration of the Hormone Circulating in Blood of Old Rats with Age-Related Hypopinealism, Probl. Endocrinol. Path., 3, pp. 56-61, (2008)
  • [9] Kvetnaya T.V., Knyaz'kin I.V., Melatonin: Rol' i znachenie v vozrastnoi patologii (Melatonin: Role and Relevance in Age-Related Pathology), (2003)
  • [10] Korkushko O.V., Khavinson V.K., Shatilo V.B., Et al., Circadian Rhythms of Pineal Gland Melatonin-Forming Function in Elderly People, Adv. Gerontol., 15, pp. 70-75, (2004)
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