Prolactin and sexuality

被引：0
作者：
Krüger T.H.C. [1 ]
Egli M. [2 ]
Leeners B. [3 ]
机构：
[1] Zentrum für Seelische Gesundheit, Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie, Arbeitsbereich Klinische Psychologie und Sexualmedizin, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover
[2] Institut für Medizintechnik Hochschule Luzern, Seestrasse 41, Hergiswil
[3] Klinik für Reproduktionsendokrinologie, Universitätsspital Zürich, Frauenklinikstrasse 10, Zürich
来源：
Gynäkologische Endokrinologie | 2017年 / 15卷 / 3期
关键词：
Arousal; Dopamine; Hyperprolactinemia; Orgasm; Secretions; prolactin;
D O I：
10.1007/s10304-017-0147-x
中图分类号：
学科分类号：
摘要：
Background: Prolactin is a versatile hormone with different functions for reproduction, sexuality, metabolism and immunity. The neuronal control of its secretion is complex and involves different hypothalamic nuclei. Animal studies were able to uncover more than 300 functions of this peptide; however, the physiological role for human sexuality and reproduction is only partly known. Objective: Presentation of the fundamental mechanisms of prolactin for sexual function and reproduction. Material and methods: Research of the literature, selection and discussion of high-quality publications. Results: This review article presents the fundamental mechanisms of prolactin production and secretion and explores specific secretion patterns with respect to sexuality and reproduction. Own studies have shown a pronounced and long-lasting prolactin secretion in men and women after orgasm as well as a possible alteration of the prolactin secretion pattern more than 48h after sexual intercourse in women. Apart from reproductive functions prolactin may also have a role for sexual satiation, satisfaction and bonding. Finally, we discuss the significance of prolactin in clinical situations, such as hyperprolactinemia and drug-induced changes of prolactin levels. Conclusion: Prolactin is a versatile hormone with various properties in sexual physiology and reproduction and alterations have a high clinical relevance; however, more ongoing research is necessary in the future. © 2017, Springer Medizin Verlag GmbH.
引用
收藏
页码：205 / 211
页数：6
相关论文
共 36 条
[1]  
Bancroft J., Janssen E., The dual control model of male sexual response: A theoretical approach to centrally mediated erectile dysfunction, Neurosci Biobehav Rev, 24, 5, pp. 571-579, (2000)
[2]  
Ben-Jonathan N., Lapensee C.R., Lapensee E.W., What can we learn from rodents about prolactin in humans?, Endocr. Rev., 29, pp. 1-41, (2008)
[3]  
De Boer M.K., Castelein S., Wiersma D., Et al., The facts about sexual (dys) function in schizophrenia: an overview of clinically relevant findings, Schizophr Bull, 41, pp. 674-686, (2015)
[4]  
Brody S., Kruger T.H., The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety, Biol Psychol, 71, pp. 312-315, (2006)
[5]  
Corona G., Wu F.C., Rastrelli G., Et al., Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: The European Male Aging Study (EMAS), J Sex Med, 11, pp. 240-253, (2014)
[6]  
Egli M., Bertram R., Sellix M.T., Et al., Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin, Endocrinology, 145, pp. 3386-3394, (2004)
[7]  
Egli M., Bertram R., Toporikova N., Et al., Prolactin secretory rhythm of mated rats induced by a single injection of oxytocin, Am. J. Physiol. Endocrinol. Metab, 290, pp. 566-572, (2006)
[8]  
Egli M., Leeners B., Kruger T.H., Prolactin secretion patterns: basic mechanisms and clinical implications for reproduction, Reproduction, 140, pp. 643-654, (2010)
[9]  
Exton M.S., Bindert A., Kruger T., Et al., Cardiovascular and endocrine alterations after masturbation-induced orgasm in women, Psychosom Med, 61, pp. 280-289, (1999)
[10]  
Exton M.S., Kruger T.H., Koch M., Et al., Coitus-induced orgasm stimulates prolactin secretion in healthy subjects, Psychoneuroendocrinology, 26, pp. 287-294, (2001)
1234