Synthesis, DNA-binding and photocleavage studies of cobalt(III) mixed-ligand complexes

被引：0
作者：
Qian-Ling Zhang
Hong Xu
Hong Li
Jie Liu
Jian-Zhong Liu
Liang-Nian Ji
Jin-Gang Liu
机构：
[1] Zhongshan University,The Key Laboratory of Gene Engineering of Ministry of Education/State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry
[2] Tongji University,Department of Chemistry
来源：
Transition Metal Chemistry | 2002年 / 27卷
关键词：
Viscosity; Physical Chemistry; Cobalt; Inorganic Chemistry; Mass Spectrum;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two novel complex ions [Co(bpy)2IP]3+ and [Co(bpy)2PIP]3+, have been prepared and characterized by EA, mass spectra, u.v.–vis., and cyclic voltammetry. The binding behavior of both complexes to calf thymus DNA (CT-DNA) has been investigated by spectroscopic methods, cyclic voltammetry, and viscosity measurements. The results suggest that both complexes bind to DNA by intercalation. Both promote cleavage of plasmid pBR 322 DNA from the supercoiled Form I to the open circular Form II upon irradiation. Mechanisms for photocleavage are proposed.
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页码：149 / 154
页数：5
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