MicroRNAs in the pathophysiology of Alzheimer’s disease and Parkinson's disease: an overview

被引：0
作者：
Mohammad Rafi Khezri
Keyvan Yousefi
Naime Majidi Zolbanin
Morteza Ghasemnejad-Berenji
机构：
[1] Urmia University of Medical Sciences,Department of Pharmacology and Toxicology, Faculty of Pharmacy
[2] University of Miami-Miller School of Medicine,Department of Molecular and Cellular Pharmacology
[3] Urmia University of Medical Sciences,Experimental and Applied Pharmaceutical Research Center
[4] Urmia University of Medical Sciences,Department of Pharmacology and Toxicology, School of Pharmacy
来源：
Molecular Neurobiology | 2022年 / 59卷
关键词：
microRNA; Alzheimer’s disease; Parkinson's disease; Neurodegenerative; CNS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neurodegenerative diseases are characterized by a progressive loss of neurons of the central nervous system (CNS) and serve as a major cause of morbidity, mortality and functional dependence especially among the elderly. Despite extensive research and development efforts, the success rate of clinical pipelines has been very limited. However, microRNAs (miRs) have been proved to be of crucial importance in regulating intracellular pathways for various pathologic conditions including those of a neurodegenerative nature. There is ample evidence of altered levels of various miRs in clinical samples of Alzheimer’s disease and Parkinson's disease patients with potentially major clinical implications. In the current review, we aim to summarize the relevant literature on the role of miRs in the pathophysiology of Alzheimer’s disease (AD) and Parkinson's disease (PD) as the two globally predominant neurodegenerative conditions.
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页码：1589 / 1603
页数：14
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