3,4-seco-24-homo-28-nor-Cycloartane and drimane-type sesquiterpenes and their lactams from the EtOAc-soluble fraction of a leaf extract of Cinnamosma fragrans and their biological activity

被引：0

作者：

Yuya Nomoto

Liva Harinantenaina

Sachiko Sugimoto

Katsuyoshi Matsunami

Hideaki Otsuka

机构：

[1] Hiroshima University,Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences

[2] Yasuda Women’s University,Department of Natural Products Chemistry, Faculty of Pharmacy

来源：

Journal of Natural Medicines | 2014年 / 68卷

关键词：

Canellaceae; -Cycloartane; Drimane; Drimane lactam; Bioassay;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

From the EtOAc-soluble fraction of a MeOH extract of leaves of Cinnamosma fragrans, seven new compounds, including 3,4-seco-24-homo-28-nor-cycloartane, drimane-type sesquiterpenes and their lactams, and two known compounds were isolated. Their structures were elucidated by extensive analyses of spectroscopic data. The cytotoxicity, anti-multidrug resistance activity, and anti-Leishmania activity of a cycloartane derivative and drimane-type sesquiterpene derivatives were assayed. The cycloartane derivative showed strong cytotoxicity, and some drimanes and drimane lactam showed moderate anti-multidrug resistance and anti-Leishmania activity.

引用

页码：513 / 520

页数：7