The Emerging Role of Epigenetics on Dietary Treatment for Epilepsy

被引：1

作者：

Landgrave-Gómez J. ^{[1
,2
]}

Vargas-Romero F. ^{[2
,3
]}

Mercado-Gómez O.F. ^{[1
]}

Guevara-Guzmán R. ^{[1
]}

机构：

[1] Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, 70250, Mexico, 04510, DF

[2] Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal

[3] Instituto de Fisiología Celular-Neurociencias, Universidad Nacional Autónoma de México, Mexico, 04510, DF

来源：

Current Nutrition Reports | 2017年 / 6卷 / 1期

关键词：

Beta-hydroxybutyrate; Dietary treatment; Epigenetics; Epilepsy; Nicotinamide adenine dinucleotide; S-Adenosyl methionine;

D O I：

10.1007/s13668-017-0189-7

中图分类号：

学科分类号：

摘要：

Purpose of Review: Seizures are able to induce a wide range of complex alterations that may be due to abnormalities in gene expression patterns. In recent years, there has been resurgence regarding the use of dietary therapies for seizure treatment. Unfortunately, the precise mechanisms by which these therapies exert its effects remain unknown. Recent Findings: Recent evidence suggest that dietary treatment, throughout a metabolic shift, could impact the concentration of some metabolites, such as beta-hydroxybutyrate (B-HB) or S-adenosyl methionine (SAM), which are able to modulate the activity of enzymes involved in regulatory processes that control gene expression. Despite of this evidence, only a few studies have fully explored this emerging field. Summary: The purpose of this article is to discuss how dietary treatment, throughout these molecules, could influence epigenetic modifications that may be able to restore aberrant patterns of gene expression produced by seizures, having an impact on this complex disease, such as seizures or even in epileptogenesis. © 2017, Springer Science+Business Media New York.

引用

页码：9 / 15

页数：6

共 56 条

[1]

Loscher W., Klitgaard H., Twyman R.E., Schmidt D., New avenues for anti-epileptic drug discovery and development, Nat Rev Drug Discov, 12, 10, pp. 757-776, (2013)

[2]

Fisher R.S., Acevedo C., Arzimanoglou A., Bogacz A., Cross J.H., Elger C.E., Et al., ILAE official report: a practical clinical definition of epilepsy, Epilepsia, 55, 4, pp. 475-482, (2014)

[3]

Huberfeld G., Vecht C.J., Seizures and gliomas towards a single therapeutic approach, Nat Rev Neurol, 12, 4, pp. 204-216, (2016)

[4]

Kossoff E.H., Nabbout R., Use of dietary therapy for status epilepticus, J Child Neurol, 28, 8, pp. 1049-1051, (2013)

[5]

Hartman A.L., Rubenstein J.E., Kossoff E.H., Intermittent fasting: a “new” historical strategy for controlling seizures?, Epilepsy Res, 104, 3, pp. 275-279, (2013)

[6]

Bough K.J., Rho J.M., Anticonvulsant mechanisms of the ketogenic diet, Epilepsia, 48, 1, pp. 43-58, (2007)

[7]

Sassone-Corsi P., When metabolism and epigenetics converge, Science, 339, 6116, pp. 148-150, (2013)

[8]

Landgrave-Gomez J., Mercado-Gomez O.F., Guevara-Guzman R., Epigenetic mechanisms in neurological and neurodegenerative diseases, Front Cell Neurosci, 9, (2015)

[9]

Roopra A., Dingledine R., Hsieh J., Epigenetics and epilepsy, Epilepsia, 53, pp. 2-10, (2012)

[10]

Lubin F.D., Epileptogenesis: can the science of epigenetics give us answers?, Epilepsy Currents, 12, 3, pp. 105-110, (2012)

← 1 2 3 4 5 6 →