Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats

被引:0
作者
Christopher M. Lack
Sara R. Jones
David C. S. Roberts
机构
[1] Wake Forest University Health Sciences,Department of Physiology and Pharmacology
来源
Psychopharmacology | 2008年 / 195卷
关键词
Addiction; Cocaine; Sensitization; Tolerance; Dopamine; Locomotor activity; Nucleus accumbens; Withdrawal; Progressive ratio;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:517 / 525
页数:8
相关论文
共 205 条
  • [1] Ahmed SH(2006)Dissociation of psychomotor sensitization from compulsive cocaine consumption Neuropsychopharmacology 31 563-571
  • [2] Cador M(1998)Transition from moderate to excessive drug intake: change in hedonic set point Science 282 298-300
  • [3] Ahmed SH(2005)Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function Psychopharmacology 180 473-490
  • [4] Koob GF(2003)Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels J Neurochem 86 102-113
  • [5] Ahmed SH(1989)Subchronic cocaine treatment enhances cocaine-induced dopamine efflux, studied by in vivo intracerebral dialysis Brain Res 490 339-344
  • [6] Koob GF(1997)A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement Pharmacol Biochem Behav 57 441-447
  • [7] Ahmed SH(1998)Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens Crit Rev Neurobiol 12 37-67
  • [8] Lin D(2004)The transition from controlled to compulsive drug use is associated with a loss of sensitization Brain Res 995 46-54
  • [9] Koob GF(2005)Prolonged daily exposure to IV cocaine results in tolerance to its stimulant effects Pharmacol Biochem Behav 82 411-416
  • [10] Parsons LH(2003)Drug addiction N Engl J Med 349 975-986