Controlling pathogenesis in Candida albicans by targeting Efg1 and Glyoxylate pathway through naturally occurring polyphenols

被引：0
作者：
Sonali Mishra
Sumit Kumar Rastogi
Sangeeta Singh
Sneh Lata Panwar
Manoj Kumar Shrivash
Krishna Misra
机构：
[1] Indian Institute of Information Technology,Department of Applied Science and Bioinformatics
[2] Jawaharlal Nehru University,Yeast Molecular Genetics Laboratory, School of Life Sciences
[3] Jamia Millia Islamia,Medical Mycology Lab, Department of Biosciences
[4] Center of Biomedical Research,undefined
[5] Babasaheb Bhimrao Ambedkar University,undefined
来源：
Molecular Biology Reports | 2019年 / 46卷
关键词：
Filamentation; Pathogenicity; Polyphenols; Antifungal; Efg1; Glyoxylate pathway;
D O I：
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中图分类号：
学科分类号：
摘要：
Candida albicans has frequently shown resistance to azoles, the commonly used antifungal drugs. Efg1 has dual role under normoxia and hypoxia supporting infection. It is the major regulator of morphogenesis in C. albicans requisite for its pathogenesis. Targeting this protein is expected to render Candida ineffective to undergo filamentation causing virulence. Further the glyoxylate pathway supports the stress resistance and pathogenesis. In the present study an in silico approach and in vitro validation has been performed to find the potential role of polyphenols in controlling hyphal growth in C. albicans. The aspect of changes biome which may provide required niche to the pathogen has been checked which certainly opens the doors towards safe natural polyphenol-based drugs as potent antifungals.
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页码：5805 / 5820
页数：15
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