Excess S-adenosylmethionine inhibits methylation via catabolism to adenine

被引：0
作者：
Kazuki Fukumoto
Kakeru Ito
Benjamin Saer
George Taylor
Shiqi Ye
Mayu Yamano
Yuki Toriba
Andrew Hayes
Hitoshi Okamura
Jean-Michel Fustin
机构：
[1] Kyoto University,Cancer Epigenetics Laboratory
[2] Graduate School of Pharmaceutical Sciences,Master’s Programme in Molecular Biology, Faculty of Science and Bioengineering Sciences
[3] Department of Molecular Metabology,undefined
[4] The University of Manchester,undefined
[5] Centre for Biological Timing,undefined
[6] The University of Manchester,undefined
[7] BioMS Core Facility,undefined
[8] The University of Manchester,undefined
[9] Genomics Technologies Core Facility,undefined
[10] Kyoto University,undefined
[11] Graduate School of Medicine,undefined
[12] Division of Physiology and Neurobiology,undefined
[13] Kokando Pharmaceutical Co.,undefined
[14] Ltd,undefined
[15] Francis Crick Institute,undefined
[16] Vrije Universiteit Brussel,undefined
来源：
Communications Biology | / 5卷
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摘要：
The global dietary supplement market is valued at over USD 100 billion. One popular dietary supplement, S-adenosylmethionine, is marketed to improve joints, liver health and emotional well-being in the US since 1999, and has been a prescription drug in Europe to treat depression and arthritis since 1975, but recent studies questioned its efficacy. In our body, S-adenosylmethionine is critical for the methylation of nucleic acids, proteins and many other targets. The marketing of SAM implies that more S-adenosylmethionine is better since it would stimulate methylations and improve health. Previously, we have shown that methylation reactions regulate biological rhythms in many organisms. Here, using biological rhythms to assess the effects of exogenous S-adenosylmethionine, we reveal that excess S-adenosylmethionine disrupts rhythms and, rather than promoting methylation, is catabolized to adenine and methylthioadenosine, toxic methylation inhibitors. These findings further our understanding of methyl metabolism and question the safety of S-adenosylmethionine as a supplement.
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