Attention deficit hyperactivity disorder

被引：0
作者：
Jonna Kuntsi
Gráinne McLoughlin
Philip Asherson
机构：
[1] King's College London,MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry
来源：
NeuroMolecular Medicine | 2006年 / 8卷
关键词：
Attention deficit hyperactivity disorder; ADHD; brain imaging; cognitive function; electrophysiology; genetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Attention deficit hyperactivity disorder (ADHD) is a behavioral diagnosis based on the presence of developmentally inappropriate levels of impulsivity, overactivity, and inattentiveness. It is a familial condition with a complex pattern of inheritance. Variation of several genes involved in the regulation of dopamine, norepinephrine, and serotonin neurotransmission is associated with ADHD. We highlight the two most prominent findings with the dopamine D4 receptor (DRD4) gene and the dopamine transporter (DAT1) gene, and their implications for the understanding of the cellular and neurobiological basis for ADHD.
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页码：461 / 484
页数：23
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  • [91] Burd L.(1999)Comparative pharmacological and functional analysis of the human dopamine D4.2 and D4.10 receptor variants Pharmacogenetics 9 561-568
  • [92] Klug M. G.(2005)Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity Biol. Psychiatry 57 229-238
  • [93] Coumbe M. J.(2003)Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors J. Pediatr. 143 104-110
  • [94] Kerbeshian J.(2000)Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes Biochemistry 39 3734-3744
  • [95] Bush G.(2003)Association of the 480-bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD Am. J. Med. Genet. B. Neuropsychiatry Genet. 121 50-54
  • [96] Frazier J. A.(2000)Lack of inhibition: a motivational deficit in children with attention deficit/hyperactivity disorder and children with traumatic brain injury Neuropsychol. Dev. Cogn. Sect. C. Child Neuropsychol. 6 286-296
  • [97] Rauch S. L.(2005)Dysfunctional attentional networks in children with attention deficit/hyperactivity disorder: evidence from an eventrelated functional magnetic resonance imaging study Biol. Psychiatry. 59 643-651
  • [98] Bush G.(2000)Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography Neurosci. Lett. 285 107-110
  • [99] Vogt B. A.(2002)Elevated striatal dopamine transporter in a drug naive patient with Tourette syndrome and attention deficity/hyperactivity disorder: positive effect of methylphenidate J. Neurol. 249 1116-1118
  • [100] Holmes J.(2001)Psychological mechanisms in hyperactivity: II. The role of genetic factors J. Child Psychol. Psychiatry 42 211-219
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