Attention deficit hyperactivity disorder

被引：0
作者：
Jonna Kuntsi
Gráinne McLoughlin
Philip Asherson
机构：
[1] King's College London,MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry
来源：
NeuroMolecular Medicine | 2006年 / 8卷
关键词：
Attention deficit hyperactivity disorder; ADHD; brain imaging; cognitive function; electrophysiology; genetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Attention deficit hyperactivity disorder (ADHD) is a behavioral diagnosis based on the presence of developmentally inappropriate levels of impulsivity, overactivity, and inattentiveness. It is a familial condition with a complex pattern of inheritance. Variation of several genes involved in the regulation of dopamine, norepinephrine, and serotonin neurotransmission is associated with ADHD. We highlight the two most prominent findings with the dopamine D4 receptor (DRD4) gene and the dopamine transporter (DAT1) gene, and their implications for the understanding of the cellular and neurobiological basis for ADHD.
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页码：461 / 484
页数：23
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  • [1] Antrop I.(2000)Stimulation seeking and hyperactivity in children with ADHD. Attention Deficit Hyperactivity Disorder J. Child. Psychol. Psychiatry 41 225-231
  • [2] Roeyers H.(1995)Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants J. Neurochem. 65 1157-1165
  • [3] Van Oost P.(2004)Attention-deficit hyperactivity disorder in the post-genomic era Eur. Child Adolesc. Psychiatry 13 150-170
  • [4] Buyssee A.(2005)Clinical assessment and treatment of attention deficit hyperactivity disorder in adults Expert Rev. Neurotherapeutics 5 525-539
  • [5] Asghari V.(2005)Unravelling the complexity of attention-deficit hyperactivity disorder: a behavioral genomic approach Br. J. Psychiatry 187 103-105
  • [6] Sanyal S.(2004)The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit hyperactivity disorder Mol. Psychiatry 9 718-726
  • [7] Buchwaldt S.(1992)Working memory Science 255 556-559
  • [8] Paterson A.(2003)Association of ADHD and conduct disorder—brain electrical evidence for the existence of a distinct subtype J. Child. Psychol. Psychiatry 44 356-376
  • [9] Jovanovic A.(2004)Questioning inhibitory control as the specific deficit of ADHD—evidence from brain electrical activity J. Neural Transm. 111 841-864
  • [10] Van Tol H. H.(1998)Attention-deficit hyperactivity disorder Sci. Am. 279 66-71
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