Thermosensitive block copolymers PEG-b-PBEMAGG containing functional pendant amino groups

被引:0
|
作者
Zhenke Wei
Qingsong Yu
Zhihua Gan
机构
[1] Chinese Academy of Sciences,The CAS Key Laboratory of Engineering Plastics, Institute of Chemistry
[2] Graduate School of Chinese Academy of Sciences,undefined
来源
Macromolecular Research | 2012年 / 20卷
关键词
thermosensitive; block copolymers; amino functional groups; poly(ethylene glycol) (PEG);
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学科分类号
摘要
A novel thermosensitive block copolymer composed of poly(ethylene glycol) (PEG) and poly(N-(N-Boc-ethylenediamine)methacryloylglycylglycylamide) (PBEMAGG) with pendant amino groups was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The thermosensitivity of these copolymers was studied with varying temperatures and block lengths of copolymers. The results indicated that the lowest critical solution temperatures (LCST) of this thermosensitive copolymer cover the range from 20 °C up to near 45 °C, and can be easily and precisely regulated by changing the block length or the amount of pendant amino groups. This copolymer with well-controlled LCST and pendant functional groups shows great potential for use as a smart drug-delivery system. [graphic not available: see fulltext]
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页码:313 / 318
页数:5
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