Clear cell odontogenic carcinoma: A diagnostic and therapeutic dilemma

被引：19
作者：
Avninder S. [1 ]
Rakheja D. [2 ]
Bhatnagar A. [3 ]
机构：
[1] Institute of Pathology-ICMR, Safdarjung Hospital Campus, New Delhi
[2] Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX
[3] Department of Cancer Surgery, Safdarjung Hospital, New Delhi
来源：
World Journal of Surgical Oncology | / 4卷 / 1期
关键词：
Mucoepidermoid Carcinoma; Odontogenic Tumor; Amelanotic Melanoma; Pectoralis Major Flap; Soft Tissue Invasion;
D O I：
10.1186/1477-7819-4-91
中图分类号：
学科分类号：
摘要：
Background: Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5th-7th decades and shows a female preponderance. It is potentially aggressive, capable of frequent recurrences and loco-regional and distant metastases. Case presentation: A 45-year-old woman presented with a radiolucent left mandibular swelling associated with loss of teeth. Left cervical lymph nodes were enlarged on palpation. The patient underwent resection of the tumor but consequent to resected margins being positive for tumor cells underwent left hemimandibulectomy with ipsilateral functional neck dissection and was free of recurrence at 8 months follow-up. Conclusion: Clear cell odontogenic carcinoma should be considered in the differential diagnosis of jaw tumors with conspicuous clear cell component. Curettage or conservative resection inevitably results in recurrences and/or metastasis and more radical resection is warranted in these tumors, especially when they are large and show soft tissue invasion. © 2006 Avninder et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 9 条
  • [1] Hansen L.S., Eversole L.R., Green T.L., Powell N.B., Clear cell odontogenic tumor-a new histologic variant with aggressive potential, Head Neck Surg, 8, pp. 115-123, (1985)
  • [2] Kramer I.R.H., Pindborg J.J., Shear M., WHO Histological Typing of Odontogenic Tumor, (1992)
  • [3] Li T.J., Yu S.F., Gao Y., Wang E.B., Clear cell odontogenic carcinoma: A clinicopathologic and immunocytochemical study of 5 cases, Arch Pathol Lab Med, 125, pp. 1566-1571, (2001)
  • [4] Fan J., Kubota E., Imamura H., Shimokama T., Tokunaga O., Katsuki T., Watanabe T., Clear cell odontogenic carcinoma: A case report with massive invasion of neighboring organs and lymph node metastasis, Oral Surg Oral Med Oral Pathol, 74, pp. 768-775, (1992)
  • [5] Bang G., Koppang H.S., Hansen L.S., Gilhuus-Moe O., Aksdal E., Persson P.G., Lundgren J., Clear cell odontogenic carcinoma: Report of three cases with pulmonary and lymph node metastasis, J Oral Pathol Med, 18, pp. 113-118, (1989)
  • [6] Milles M., Doyle J., Mesa M., Raz S., Clear cell odontogenic carcinoma with lymph node metastasis, Oral Surg Oral Med Oral Pathol, 76, pp. 82-89, (1993)
  • [7] Eversole L.R., Malignant epithelial odontogenic tumors, Semin Diagn Pathol, 16, pp. 317-324, (1999)
  • [8] Braunshtein E., Vered M., Taicher S., Buchner A., Clear cello dontogenic carcinoma and clear cell ameloblastoma: A single clinicopathologic entity? A new case and comparative analysis of the literature, J Oral Maxillofac Surg, 61, pp. 1004-1010, (2003)
  • [9] Ebert C.S., Dubin M.G., Hart C.F., Chalian A.A., Shockley W.W., Clear cell odontogenic carcinoma: A comprehensive analysis of treatment strategies, Head Neck, 27, pp. 536-542, (2005)
1