Birth asphyxia as the major complication in newborns: Moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care

被引：64
作者：
Golubnitschaja O. [1 ]
Yeghiazaryan K. [1 ]
Cebioglu M. [1 ]
Morelli M. [2 ]
Herrera-Marschitz M. [3 ,4 ]
机构：
[1] Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn
[2] Department of Toxicology, Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari
[3] Department of Pharmacology, Karolinska Institute, Stockholm
[4] Programme of Molecular and Clinical Pharmacology, University of Chile, Santiago
来源：
EPMA Journal | 2011年 / 2卷 / 2期
关键词：
Cancer; CNS injury; Diabetes; Neurodegeneration; Paediatrics; Personalised medicine;
D O I：
10.1007/s13167-011-0087-9
中图分类号：
学科分类号：
摘要：
Perinatal Asphyxia-oxygen deficit at delivery-can lead to severe hypoxic ischaemic organ damage in newborns followed by a fatal outcome or severe life-long pathologies. The severe insults often cause neurodegenerative diseases, mental retardation and epilepsies. The mild insults lead to so-called "minimal brain-damage disorders" such as attention deficits and hyperactivity, but can also be associated with the development of schizophrenia and life-long functional psychotic syndromes. Asphyxia followed by re-oxygenation can potentially lead to development of several neurodegenerative pathologies, diabetes type 2 and cancer. The task of individual prediction, targeted prevention and personalised treatments before a manifestation of the life-long chronic pathologies usually developed by newborns with asphyxic deficits, should be given the extraordinary priority in neonatology and paediatrics. Socio-economical impacts of educational measures and advanced strategies in development of robust diagnostic approaches targeted at effected molecular pathways, biomarker-candidates and potential drug-targets for tailored treatments are reviewed in the paper. © 2011 European Association for Predictive, Preventive and Personalised Medicine.
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页码：197 / 210
页数：13
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