Effects of high-fat mixed-lipid diet and exercise on the antioxidant system in skeletal and cardiac muscles of rats with colon carcinoma

被引：0
作者：
Martina Perše
Rade Injac
Borut Štrukelj
Anton Cerar
机构：
[1] University of Ljubljana,Institute of Pathology, Medical Experimental Centre, Medical Faculty
[2] University of Ljubljana,Faculty of Pharmacy, Institute of Pharmaceutical Biology
来源：
Pharmacological Reports | 2009年 / 61卷
关键词：
colon carcinoma; antioxidants; oxidative stress; fat; exercise; heart; muscle;
D O I：
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中图分类号：
学科分类号：
摘要：
Epidemiological and experimental studies suggest that eating habits and a sedentary lifestyle play a critical role in the incidence of colon carcinoma. In order to investigate the effects of high-fat mixed-lipid (HFML) diet in conjunction with long-term swimming, the antioxidant capacity of skeletal and cardiac muscles were observed in rats with 1, 2-dimethylhydrazine (DMH)-induced colon carcinoma. Male Wistar rats were randomly divided into one control group and four cancer groups: sedentary and swimming groups fed low fat corn oil diet and sedentary and swimming groups, fed aHFMLdiet. After 6monthsofswimming, rats were sacrificed and the blood, cardiac and soleus muscle were taken for analysis. Serum cholesterol, triglyceride and glucose concentrations were measured and the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase as well as levels of malondial-dehyde and glutathione were determined.
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页码：909 / 916
页数：7
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