Inclusion Body Myositis

被引：0
作者：
Mazen M. Dimachkie
Richard J. Barohn
机构：
[1] University of Kansas Medical Center,Department of Neurology
来源：
Current Neurology and Neuroscience Reports | 2013年 / 13卷
关键词：
Inclusion body myositis; Idiopathic inflammatory myopathies; Polymyositis; Pathology; Pathophysiology; Treatment; Prognosis;
D O I：
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学科分类号：
摘要：
Sporadic inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy (IIM) after age 50 years. It presents with chronic insidious proximal leg and distal arm asymmetric muscle weakness. Despite similarities with polymyositis (PM), it is likely that IBM is primarily a degenerative disorder rather than inflammatory muscle disease. IBM is associated with a modest degree of creatine kinase (CK) elevation and an electromyogram (EMG) demonstrates a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibers often times accompanied by rimmed vacuoles. We review IBM with emphasis on recent developments in the field and discuss ongoing clinical trials.
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