Research progress of SWI/SNF complex in breast cancer

被引：0
作者：
Kexuan Li
Baocai Wang
Haolin Hu
机构：
[1] Southeast University,School of Medicine
[2] Technical University of Munich,Department of Surgery, TUM School of Medicine, Klinikum rechts der Isar
[3] Southeast University,Breast Center, Zhongda Hospital, School of Medicine
来源：
Epigenetics & Chromatin | / 17卷
关键词：
Breast cancer; Epigenetics; SWI/SNF; Chromatin remodeling;
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摘要：
In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SNF complex is an ATP-dependent chromatin remodeling complex whose mutations are associated with various malignancies including breast cancer. As the SWI/SNF complex has become one of the most commonly mutated complexes in cancer, targeting epigenetic mutations acquired during breast cancer progress is a potential means of improving clinical efficacy in treatment strategies. This article reviews the composition of the SWI/SNF complex, its main roles and research progress in breast cancer, and links these findings to the latest discoveries in cancer epigenomics to discuss the potential mechanisms and therapeutic potential of SWI/SNF in breast cancer.
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