Influence of selenium (antioxidant) on gliclazide induced hypoglycaemia/anti hyperglycaemia in normal/alloxan-induced diabetic rats

被引：0
作者：
S. Satyanarayana
J. Rajad Sekhar
K. Eswar Kumar
L. Bacchus Shannika
Bettaiya Rajanna
Sharada Rajanna
机构：
[1] Andhra University,University College of Pharmaceutical Sciences
[2] Alcorn State University,Department of Biological Sciences
[3] Andhra University,Pharmacology Division, University College of Pharmaceutical Sciences
来源：
Molecular and Cellular Biochemistry | 2006年 / 283卷
关键词：
antihyperglycaemia; blood glucose; diabetes; gliclazide; hypoglycaemia; selenium;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Oxidative stress is involved in diabetes mellitus and its complications. Since diabetes is a stress-related disorder, supplementation with antioxidants may improve the condition. The purpose of this study is to know the effect of oral administration of selenium on blood glucose and its influence on gliclazide induced hypoglycaemia/antihyperglycaemia in normal and alloxan-induced diabetic rats. Albino rats of either sex were divided into three groups of six each. Group-I/II/III were treated with selenium 1/2 TD (0.9 μg/200 g rat)/TD (1.8 μg/200 g rat)/2TD (3.6 μg/200 g rat), respectively. Later group II was treated with gliclazide TD (1.44 mg/200 g rat)/selenium TD + gliclazide TD with a washout period of 1 week between the treatments. Diabetes was induced by alloxan monohydrate 100 mg/kg body weight i.p. A group of six rats showing fasting blood glucose levels ranging from 175–250 mg/dl were selected for the study. Rats were treated with selenium TD, gliclazide TD and selenium TD + gliclazide TD with a washout period of 1 week between the treatments. Selenium 1/2 TD and TD produced hypoglycaemia while 2TD produced hyperglycaemia. The combination of selenium TD with gliclazide TD, significantly enhanced the glucose lowering effect of gliclazide in normal and diabetic rats.
引用
收藏
页码：123 / 127
页数：4
相关论文
共 68 条
  • [1] Kingh H(1998)Prevalence: numerical estimates and projections. Global burden of diabetes, 1995–2025 Diabetes Care 21 1414-1431
  • [2] Aubert RE(1994)Hemobiological properties of gliclazide J Diabetes Complicat 8 235-239
  • [3] Heiman WH(1990)Freeradical activity in type diabetes Diabetic Med 7 27-30
  • [4] Ziegler P(1997)Relationships between plasma measures of oxidative stress and metabolic control in NIDDM Diabetologia 40 647-653
  • [5] Drouin P(2005)Influence of anti oxidant (L-ascorbic acid) on tolbutamide-induced hypoglycaemia/anti hyperglycaemia in normal and diabetic rats BMC endocrine disorders 5 2-392
  • [6] Collier A(1999)Selenium in diabetes: Effects of selenium on nephropathy in type-I streptozotociun induced diabetic rats J Trace Elem Exp Med 12 379-1937
  • [7] Wilson R(1969)Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor Ann Clin Biochem 6 24-124
  • [8] Bradley H(2001)Effect of antioxidant treatment on streptozotocin induced diabetic rats on endoneural blood flow, motor nerve conduction velocity and vascular reactivity of epineural arterioles of the sciatic nerve Diabetes 50 1927-180
  • [9] Thomson JA(1988)Free radicals and diabetes Free Radic Biol Med 5 113-1171
  • [10] Small M(2000)Radicals and oxidative stress in diabetes Diabetic Med 17 171-253
1234567