Targeted therapy in the treatment of solid tumors: Practice contradicts theory

被引：0
作者：
N. V. Zhukov
S. A. Tjulandin
机构：
[1] Ministry of Health Care and Social Security of the Russian Federation,Federal Research
[2] Russian Academy of Medical Sciences,Clinical Center for Pediatric Hematology, Oncology, and Immunology
来源：
Biochemistry (Moscow) | 2008年 / 73卷
关键词：
targeted therapy; breast cancer; colorectal cancer; VEGF; VEGFR; EGFR; HER-2;
D O I：
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学科分类号：
摘要：
The basic principle of targeted therapy formulated about ten years ago consists in the design and application of drugs specifically directed against well-defined targets that are critical for tumor survival and not compromising for normal organs and tissues. The past decade has been marked by the appearance of an immense diversity of novel antitumor agents with claimed targeted action. Unfortunately, despite indisputable progress in clinical settings, some popular drugs against solid tumors (e.g. bevacizumab, trastuzumab, erlotinib, gefitinib) nominally assigned to targeted-action drugs, cannot actually be classified with this group being nonconforming to a priori stated goals of targeted therapy. The state-of-the-art and current problems in targeted therapy of solid tumors are reviewed.
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[11]  
Selig M.(2005)undefined Breast Cancer Res. Treat. 94 S6-985
[12]  
Nielsen G.(1983)undefined Science 219 983-10599
[13]  
Taksir T.(1996)undefined Proc. Natl. Acad. Sci. USA 93 10595-676
[14]  
Jain R. K.(2003)undefined Nat. Med. 9 669-2342
[15]  
Seed B.(2004)undefined N. Engl. J. Med. 350 2335-1544
[16]  
Peichev M.(2007)undefined J. Clin. Oncol. 25 1539-422
[17]  
Naiyer A. J.(2003)undefined Clin. Breast Cancer 3 421-799
[18]  
Pereira D.(2005)undefined J. Clin. Oncol. 23 792-2550
[19]  
Zhu Z.(2006)undefined N. Engl. J. Med. 355 2542-5171
[20]  
Lane W. J.(2007)undefined J. Clin. Oncol. 25 5165-66
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