Structure of the AcrAB–TolC multidrug efflux pump

被引：0
作者：
Dijun Du
Zhao Wang
Nathan R. James
Jarrod E. Voss
Ewa Klimont
Thelma Ohene-Agyei
Henrietta Venter
Wah Chiu
Ben F. Luisi
机构：
[1] University of Cambridge,Department of Biochemistry
[2] Tennis Court Road,Verna and Marrs McLean Department of Biochemistry and Molecular Biology
[3] Cambridge CB2 1GA,Department of Pharmacology
[4] UK,undefined
[5] National Center for Macromolecular Imaging,undefined
[6] Baylor College of Medicine,undefined
[7] Tennis Court Road,undefined
[8] Cambridge CB2 1PD,undefined
[9] UK,undefined
[10] School of Pharmacy & Medical Sciences,undefined
[11] Sansom Institute for Health Research,undefined
[12] University of South Australia,undefined
来源：
Nature | 2014年 / 509卷
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摘要：
Many bacteria are able to survive in the presence of antibiotics in part because they possess pumps that can remove a broad range of small molecules; here, the structure of one such pump, AcrAB–TolC, is determined using X-ray crystallography and cryo-electron microscopy.
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页码：512 / 515
页数：3
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