Pharmacokinetic study of BSH and BPA in simultaneous use for BNCT

被引：0
作者：
Kunio Yokoyama
Shin-Ichi Miyatake
Yoshinaga Kajimoto
Shinji Kawabata
Atsushi Doi
Toshiko Yoshida
Tomoyuki Asano
Mitsunori Kirihata
Koji Ono
Toshihiko Kuroiwa
机构：
[1] Osaka Medical College,Department of Neurosurgery
[2] Toyama Medical and Pharmaceutical University,Department of Anatomy
[3] Osaka Prefectural University,Department of Agriculture
[4] Kyoto University,Particle Radiation Oncology Research Center, Research Reactor Institute
[5] Osaka Medical College,Department of Neurosurgery
来源：
Journal of Neuro-Oncology | 2006年 / 78卷
关键词：
BNCT; BPA; BSH; glioma; ICP-AES;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In order to improve the effectiveness of boron neutron capture therapy (BNCT) for malignant gliomas, we examined the optimization of the administration of boron compounds in brain tumor animal model. We analyzed the concentration of boron atoms in intracranial C6 glioma -bearing rats using inductively coupled plasma atomic emission spectrometry. Each tumor-bearing rat received one of two different amounts of sodium borocaptate (BSH) and/or 500 mg/kg of boronophenylalanine (BPA) via intraperitoneal injection. We compared the boron concentrations of the tumor, the contralateral normal brain and the blood in rats of 3 different treatment groups (BSH alone, BPA alone and a combination of both BSH and BPA).
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页码：227 / 232
页数：5
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