Time to decide about risk-reducing mastectomy: A case series of BRCA1/2 gene mutation carriers

被引：12
作者：
McCullum M. [1 ]
Bottorff J.L. [2 ,3 ]
Kelly M. [2 ]
Kieffer S.A. [2 ,4 ]
Balneaves L.G. [2 ]
机构：
[1] Hereditary Cancer Program, BC Cancer Agency, Vancouver, BC
[2] School of Nursing, University of British Columbia, Vancouver, BC
[3] Faculty of Health and Social Development, University of British Columbia - Okanagan, Kelowna, BC
[4] Department of Medical Genetics, University of British Columbia, Vancouver, BC
来源：
BMC Women's Health | / 7卷 / 1期
关键词：
Breast Cancer; Breast Cancer Risk; Breast Reconstruction; Breast Cancer Screening; Decision Conflict;
D O I：
10.1186/1472-6874-7-3
中图分类号：
学科分类号：
摘要：
Background: The purpose of this research was to explore women's decision-making experiences related to the option of risk-reducing mastectomy (RM), using a case series of three women who are carriers of a BRCA1/2 gene mutation. Methods: Data was collected in a pilot study that assessed the response of women to an information booklet about RM and decision-making support strategies. A detailed analysis of three women's descriptions of their decision-making processes and outcomes was conducted. Results: All three women were carriers of a BRCA1/2 gene mutation and, although undecided, were leaning towards RM when initially assessed. Each woman reported a different RM decision outcome at last follow-up. Case #1 decided not to have RM, stating that RM was "too radical" and early detection methods were an effective strategy for dealing with breast cancer risk. Case #2 remained undecided about RM and, over time, she became less prepared to make a decision because she felt she did not have sufficient information about surgical effects. Case #3 had undergone RM by the time of her second follow-up interview and reported that she felt "a load off (her) mind now". Conclusion: RM decision making may shift over time and require decision support over an extended period. © 2007 McCullum et al; licensee BioMed Central Ltd.
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