mRNA structures control the post-transcriptional gene regulation

被引：0

作者：

Lichtenthaeler C. ^{[1
]}

Oberstrass L. ^{[1
]}

Weigand J.E. ^{[1
]}

机构：

[1] Fachbereich Biologie, Technische Universität Darmstadt, Schnittspahnstraße 10, Darmstadt

来源：

BIOspektrum | 2021年 / 27卷 / 4期

关键词：

D O I：

10.1007/s12268-021-1600-x

中图分类号：

学科分类号：

摘要：

Posttranscriptional regulation at mRNA level is defined not only by sequence, but also by the structure of the mRNA. Structures in the untranslated regions control stability, translation and localization of an mRNA. Evolutionary conservation can be used to identify such regulatory active structures in mRNAs. For example, constitutive decay element (CDE) stem-loops are recognized by Roquin proteins in an exclusively shape-specific manner. Strikingly, some CDEs can serve a dual function in gene repression depending on their folding status. © 2021, Die Autoren.

引用

页码：351 / 354

页数：3

共 10 条

[1]

Wacker A., Weigand J.E., Akabayov S.R., Et al., Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy, Nucleic Acids Res, 48, pp. 12415-12435, (2020)

[2]

Braun J., Fischer S., Xu Z.Z., Et al., Identification of new high affinity targets for Roquin based on structural conservation, Nucleic Acids Res, 46, pp. 12109-12125, (2018)

[3]

Pohl E.E., Rupprecht A., Macher G., Et al., Important trends in UCP3 investigation, Front Physiol, 10, (2019)

[4]

Leppek K., Schott J., Reitter S., Et al., Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs, Cell, 153, pp. 869-881, (2013)

[5]

Schlundt A., Heinz G.A., Janowski R., Et al., Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation, Nat Struct Mol Biol, 21, pp. 671-678, (2014)

[6]

von Roretz C., Marco S.D., Mazroui R., Et al., Turnover of AU-rich-containing mRNAs during stress: a matter of survival, WIREs RNA, 2, pp. 336-347, (2011)

[7]

van Nostrand E.L., Freese P., Pratt G.A., Et al., A large-scale binding and functional map of human RNA-binding proteins, Nature, 583, pp. 711-719, (2020)

[8]

Codutti L., Leppek K., Zalesak J., Et al., A distinct, sequence-induced conformation is required for recognition of the constitutive decay element RNA by Roquin, Structure, 23, pp. 1437-1447, (2015)

[9]

Janowski R., Heinz G.A., Schlundt A., Et al., Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40, Nat Commun, 7, (2016)

[10]

Binas O., Tants J.-N., Peter S.A., Et al., Structural basis for the recognition of transiently structured AU-rich elements by Roquin, Nucleic Acids Res, 48, pp. 7385-7403, (2020)

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