Safety and Pharmacokinetics of HRS-2261, a P2X3 Receptor Antagonist, in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study

[1] Chung KF(2022)Cough hypersensitivity and chronic cough Nat Rev Dis Primers 8 45-492

[2] McGarvey L(2004)The diagnosis and management of chronic cough Eur Respir J 24 481-1551

[3] Song WJ(2016)Chronic cough N Engl J Med 375 1544-1374

[4] Chang AB(2008)Prevalence, pathogenesis, and causes of chronic cough Lancet 371 1364-1481

[5] Lai K(2015)The global epidemiology of chronic cough in adults: a systematic review and meta-analysis Eur Respir J 45 1479-4044 e4032

[6] Canning BJ(2021)Impact and disease burden of chronic cough Asia Pac Allergy 11 4037-87

[7] Birring SS(2021)Prevalence and burden of chronic cough in the United States J Allergy Clin Immunol Pract 9 S82-27

[8] Smith JA(2008)Currently available cough suppressants for chronic cough Lung 186 19-923

[9] Mazzone SB(2005)Drugs to suppress cough Expert Opin Investig Drugs 14 909-785

[10] Morice AH(2022)Treatment of chronic cough: P2X3 receptor antagonists and beyond Pharmacol Ther 237 775-695

[1] Chung KF(2022)Cough hypersensitivity and chronic cough Nat Rev Dis Primers 8 45-492

[2] McGarvey L(2004)The diagnosis and management of chronic cough Eur Respir J 24 481-1551

[3] Song WJ(2016)Chronic cough N Engl J Med 375 1544-1374

[4] Chang AB(2008)Prevalence, pathogenesis, and causes of chronic cough Lancet 371 1364-1481

[5] Lai K(2015)The global epidemiology of chronic cough in adults: a systematic review and meta-analysis Eur Respir J 45 1479-4044 e4032

[6] Canning BJ(2021)Impact and disease burden of chronic cough Asia Pac Allergy 11 4037-87

[7] Birring SS(2021)Prevalence and burden of chronic cough in the United States J Allergy Clin Immunol Pract 9 S82-27

[8] Smith JA(2008)Currently available cough suppressants for chronic cough Lung 186 19-923

[9] Mazzone SB(2005)Drugs to suppress cough Expert Opin Investig Drugs 14 909-785

[10] Morice AH(2022)Treatment of chronic cough: P2X3 receptor antagonists and beyond Pharmacol Ther 237 775-695