Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health

被引：0
作者：
Undraga Schagdarsurengin
Klaus Steger
机构：
[1] Pediatric Urology and Andrology,Department of Urology
[2] Section Molecular Andrology,undefined
[3] Justus-Liebig-University,undefined
来源：
Nature Reviews Urology | 2016年 / 13卷
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摘要：
Spermatozoa have a unique epigenetic signature, consisting of their DNA methylation profile, DNA-associated proteins, protamine 1:protamine 2 ratio, nucleosome distribution pattern, post-translational histone modifications, stored RNA and nonhistone and nonprotamine proteinsDietary compounds, especially phytochemicals, minerals and vitamins, can effect changes in epigenetic signatures of somatic as well as germ cells by influencing enzymes and other proteins responsible for epigenetic modificationsModifications of the epigenetic landscape by dietary compounds can affect overall health but also the reproductive health of both sexesStudies in animal models and human epidemiological data point toward a transgenerational effect of parental nutrition on offspring healthMale germ cell development can be divided into distinct stages, each representing a time window of susceptibility to epigenetic alterations, resulting in specific epigenetic changes in descendants and their phenotypes
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页码：584 / 595
页数：11
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