Three atypical BCR/ABL transcripts detected simultaneously in a Philadelphia-positive acute lymphoblastic leukemia patient showing resistance to tyrosine kinase inhibitors

被引：0

作者：

Haimin Sun

Zeying Yan

Sujiang Zhang

机构：

[1] Ruijin Hospital,Department of Hematology

[2] Shanghai Jiao Tong University School of Medicine,State Key Laboratory of Medical Genomics

[3] Shanghai Institute of Hematology,undefined

[4] National Research Center for Translational Medicine at Shanghai,undefined

[5] Ruijin Hospital,undefined

[6] Shanghai Jiao Tong University School of Medicine,undefined

来源：

International Journal of Hematology | 2023年 / 117卷

关键词：

Acute lymphoblastic leukemia; BCR/ABL; Tyrosine kinase inhibitors;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The Philadelphia (Ph) chromosome with a BCR/ABL fusion gene is a characteristic feature of chronic myeloid leukemia (CML) and partial acute lymphoblastic leukemia (ALL) patients, with different breakpoints of the BCR and ABL genes. Here, we report the case of a Ph-positive ALL patient with poor prognosis in whom simultaneous different BCR/ABL transcripts named e1a3, e1a4, and e1a5 were detected by RNA-seq analysis but not traditional RT-PCR. To our knowledge, this is the first report to describe coexistence of different atypical BCR–ABL transcripts in the same patient and that traditional TKI therapy may not overcome the poor prognosis. This finding will bring new challenges in diagnosis and monitoring for minimal residual disease.

引用

页码：134 / 136

页数：2

共 38 条

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