Synthesis and anti-inflammatory and analgesic activities of pyridyloxy- and phenoxyalkanoic acid derivatives

被引：0
作者：
Kuk Hyun Shin
Soon Sung Lim
Sang Hoon Jung
Jun Ji
Eun Bang Lee
Dong Chan Kim
Kye Jung Shin
Dong Jin Kim
Sang Woo Park
机构：
[1] Seoul National University,Natural Products Research Institute
[2] Korea Institute of Science and Technology,Division of Applied Sciences
来源：
Archives of Pharmacal Research | 2000年 / 23卷
关键词：
Pyridyloxyalkanate; Pyridyloxyphenoxyalkanate; Phenoxylphenoxyalkanate; Anti-inflammatory activity; Analgesic activity; Carrageenin-induced paw edema; Acetic acid writhing syndrome; Tail clip pressure test;
D O I：
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学科分类号：
摘要：
Synthesis of pyridyloxy-, pyridyloxyphenoxy- and phenoxylphenoxyalkanate derivatives and their anti-inflammatory and analgesic activities were investigated. Analysis of structure-activity relationships showed that in pyridyloxyalkanoic acid derivatives anti-edematous potency was associated with the presence of chlorophenoxypropionic acid moiety and 2-nitrated methyl propionates contributed to the analgesic activity.
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页码：17 / 21
页数：4
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Shin K. H.(undefined)undefined undefined undefined undefined-undefined
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Lee E. B.(undefined)undefined undefined undefined undefined-undefined
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