The potential of the immunological markers of sarcoidosis in exhaled breath and peripheral blood as future diagnostic and monitoring techniques

被引：15
作者：
Ahmadzai H. [1 ,2 ]
Wakefield D. [1 ,3 ]
Thomas P.S. [1 ,2 ]
机构：
[1] Inflammation and Infection Research Centre, Faculty of Medicine, University of New South Wales, Sydney
[2] Department of Respiratory Medicine, Prince of Wales Hospital, Randwick
[3] Immunology of the Eye Clinic, St. Vincent's Clinic, Darlinghurst
来源：
Inflammopharmacology | 2011年 / 19卷 / 2期
关键词：
Exhaled breath condensate; Flow cytometry; Inflammatory markers; Kveim-Siltzbach test; Sarcoidosis; T [!sub]H[!/sub]1/T [!sub]H[!/sub]2 balance; T [!sub]H[!/sub]17 cytokine measurement;
D O I：
10.1007/s10787-011-0079-3
中图分类号：
学科分类号：
摘要：
Sarcoidosis is characterised by non-caseating granulomatous inflammation, with exaggerated immune responses at sites of disease and derangements of normal tissue architecture. The lungs are most commonly involved and progressive inflammation may result in pulmonary fibrosis. The immunopathogenesis and aetiology remain uncertain, which has made it difficult to identify a single sufficiently sensitive or specific diagnostic marker. Further investigation is needed to identify sensitive and specific markers of disease, such as in peripheral blood and exhaled breath condensate (EBC). Identification of disease markers may also be useful for investigating disease activity and predicting progression to fibrosis. This review explores the literature on the cytokine profiles of blood and bronchoalveolar lavage lymphocytes following ex vivo stimulation, as well as disease markers measured using the medium of EBC. © Springer Basel AG 2011.
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页码：55 / 68
页数：13
相关论文
共 164 条
[1]  
Agostini C., Adami F., Semenzato G., New pathogenetic insights into the sarcoid granuloma, Curr Opin Rheumatol, 12, pp. 71-76, (2000)
[2]  
Agostini C., Meneghin A., Semenzato G., T-lymphocytes and cytokines in sarcoidosis, Curr Opin Pulm Med, 8, 5, pp. 435-440, (2002)
[3]  
Akahoshi M., Ishihara M., Remus N., Uno K., Miyake K., Hirota T., Nakashima K., Matsuda A., Kanda M., Enomoto T., Ohno S., Nakashima H., Casanova J., Hopkin J.M., Tamari M., Mao X., Shirakawa T., Association between IFNA genotype and the risk of sarcoidosis, Hum Genet, 114, pp. 503-509, (2004)
[4]  
Allen R.K., Pierce R.J., Barter C.E., Angiotensin-converting enzyme in bronchoalveolar lavage fluid in sarcoidosis, Sarcoidosis, 9, 1, pp. 54-59, (1992)
[5]  
Allen S.S., Evans W., Carlisle J., Hajizadeh R., Nadaf M., Shepherd B.E., Pride D.T., Johnson J.E., Drake W.P., Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses, Respir Res, 9, pp. 36-47, (2008)
[6]  
Antoniou K.M., Soufla G., Proklou A., Margaritopoulos G., Choulaki C., Lymbouridou R., Samara K.D., Spandidos D.A., Siafakas N.M., Different activity of the biological axis VEGF-Flt-1 (fms-like tyrosine kinase 1) and CXC chemokines between pulmonary sarcoidosis and idiopathic pulmonary fibrosis: A bronchoalveolar lavage study, Clin Dev Immunol, (2009)
[7]  
Bargagli E., Mazzi A., Rottoli P., Markers of inflammation in sarcoidosis: Blood, urine, BAL, sputum, and exhaled gas, Clin Chest Med, 29, 3, pp. 445-458, (2008)
[8]  
Baughman R.P., Lower E.E., Du Bois R.M., Sarcoidosis, Lancet, 361, pp. 1111-1118, (2003)
[9]  
Beirne P., Pantelidis P., Charles P., Wells A.U., Abraham D.J., Denton C.P., Welsh K.I., Shah P.L., Du Bois R.M., Kelleher P., Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis, Eur Respir J, 34, 6, pp. 1376-1382, (2009)
[10]  
Berge B.T., Paats M.S., Bergen I.M., Van Den Blink B., Hoogsteden H.C., Lambrecht B.N., Hendriks R.W., KleinJan A., IL-17 and IL-22 expressing cells are involved in granuloma pathogenesis in pulmonary sarcoidosis, Am J Respir Crit Care Med, 181, 1, (2010)
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